※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM), includes protein phosphatases which dependent on manganese/magnesium ions (Mn2+/Mg2+). PPM family contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determine the substrate recognition and function diversity. Like PPP family, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is the largest protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor proteins (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (16) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-TAG-00025	ENSTGUG00000002504	PPM1K
2		EPS-TAG-00031	ENSTGUG00000008329	PHLPP2
3		EPS-TAG-00035	ENSTGUG00000016606
4		EPS-TAG-00024	ENSTGUG00000006550	ILKAP
5		EPS-TAG-00030	ENSTGUG00000007416	PPM1E
6		EPS-TAG-00023	ENSTGUG00000012997	PPM1A
7		EPS-TAG-00029	ENSTGUG00000008628	PPM1F
8		EPS-TAG-00022	ENSTGUG00000003793	PPM1B
9		EPS-TAG-00037	ENSTGUG00000017530	PPM1J
10		EPS-TAG-00033	ENSTGUG00000006115	PPM1M
11		EPS-TAG-00028	ENSTGUG00000007882	PPM1D
12		EPS-TAG-00027	ENSTGUG00000011154	PPM1L
13		EPS-TAG-00026	ENSTGUG00000002028	PHLPP1
14		EPS-TAG-00036	ENSTGUG00000006354	PPM1H
15		EPS-TAG-00034	ENSTGUG00000010239	TAB1
16		EPS-TAG-00032	ENSTGUG00000014753	PPM1G