※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAR-00436	ENSTRUG00000003071	MINK1 (2 of 2)
2		EKS-TAR-00419	ENSTRUG00000013107	MAP4K3
3		EKS-TAR-00416	ENSTRUG00000013185	MAP4K2
4		EKS-TAR-00437	ENSTRUG00000011020	STRADA
5		EKS-TAR-00431	ENSTRUG00000017818	MYO3B
6		EKS-TAR-00439	ENSTRUG00000002623	OXSR1 (3 of 3)
7		EKS-TAR-00429	ENSTRUG00000002844	TAOK2; TAOK2 (1 of 2)
8		EKS-TAR-00414	ENSTRUG00000014381	PAK2 (2 of 2)
9		EKS-TAR-00403	ENSTRUG00000012274	TNIK (2 of 2)
10		EKS-TAR-00406	ENSTRUG00000006376	MAP4K4 (2 of 2)
11		EKS-TAR-00418	ENSTRUG00000006511
12		EKS-TAR-00430	ENSTRUG00000012917	PAK6 (1 of 2)
13		EKS-TAR-00422	ENSTRUG00000001369	STK10
14		EKS-TAR-00411	ENSTRUG00000015001	STK3
15		EKS-TAR-00407	ENSTRUG00000015124	MAP4K4 (1 of 2)
16		EKS-TAR-00413	ENSTRUG00000009167	MAP4K5
17		EKS-TAR-00435	ENSTRUG00000005168	TAOK1 (2 of 2)
18		EKS-TAR-00420	ENSTRUG00000000941	STK4
19		EKS-TAR-00427	ENSTRUG00000000317	TAOK1 (1 of 2)
20		EKS-TAR-00409	ENSTRUG00000000410	STK25
21		EKS-TAR-00434	ENSTRUG00000004444	PAK6 (2 of 2)
22		EKS-TAR-00440	ENSTRUG00000000738	STK39 (2 of 2)
23		EKS-TAR-00405	ENSTRUG00000004976	PAK1; PAK1 (1 of 2)
24		EKS-TAR-00428	ENSTRUG00000000555	STK39 (1 of 2)
25		EKS-TAR-00424	ENSTRUG00000009412	OXSR1 (1 of 3)
26		EKS-TAR-00421	ENSTRUG00000009332	SLK (2 of 2)
27		EKS-TAR-00415	ENSTRUG00000016233	PAK2 (1 of 2)
28		EKS-TAR-00433	ENSTRUG00000016256	TAOK3 (1 of 2)
29		EKS-TAR-00402	ENSTRUG00000016332	MINK1 (1 of 2)
30		EKS-TAR-00426	ENSTRUG00000009772	PAK7
31		EKS-TAR-00408	ENSTRUG00000016790	PAK1 (2 of 2)
32		EKS-TAR-00438	ENSTRUG00000010953	STRADB
33		EKS-TAR-00417	ENSTRUG00000008924	MAP4K1
34		EKS-TAR-00404	ENSTRUG00000003746	TNIK (1 of 2)
35		EKS-TAR-00423	ENSTRUG00000008318	PAK4
36		EKS-TAR-00432	ENSTRUG00000008333	TAOK2 (2 of 2)
37		EKS-TAR-00412	ENSTRUG00000008054	STK24 (1 of 2)
38		EKS-TAR-00410	ENSTRUG00000017397	STK24 (2 of 2)
39		EKS-TAR-00425	ENSTRUG00000008662	SLK (1 of 2)