※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MOD-00006	ENSMODG00000017007	EPHA6
2		EKS-MOD-00012	ENSMODG00000000983	EPHB6
3		EKS-MOD-00011	ENSMODG00000001465	EPHA1
4		EKS-MOD-00013	ENSMODG00000017759	EPHA10
5		EKS-MOD-00007	ENSMODG00000018518	EPHB1
6		EKS-MOD-00004	ENSMODG00000018150	EPHA7
7		EKS-MOD-00001	ENSMODG00000021189	EPHA4
8		EKS-MOD-00009	ENSMODG00000003309	EPHA2
9		EKS-MOD-00003	ENSMODG00000020730	EPHA5
10		EKS-MOD-00005	ENSMODG00000016114	EPHB2
11		EKS-MOD-00010	ENSMODG00000016101	EPHA8
12		EKS-MOD-00008	ENSMODG00000004739	EPHB4
13		EKS-MOD-00002	ENSMODG00000016972	EPHA3