※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (12)  or Unreviewed (0) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MUM-00307	ENSMUSG00000000532	Acvr1b; Alk4
2		EKS-MUM-00312	ENSMUSG00000000530	Acvrlk1, Alk-1; Acvrl1
3		EKS-MUM-00309	ENSMUSG00000052430	Bmpr1b; Acvrlk6
4		EKS-MUM-00313	ENSMUSG00000052155	Acvr2a; Acvr2
5		EKS-MUM-00311	ENSMUSG00000021796	Bmpr1a; Acvrlk3, Bmpr
6		EKS-MUM-00306	ENSMUSG00000007613	Tgfbr1
7		EKS-MUM-00314	ENSMUSG00000061393	Acvr2b
8		EKS-MUM-00308	ENSMUSG00000026834	Acvr1c; Alk7
9		EKS-MUM-00310	ENSMUSG00000026836	Acvrlk2, Tgfb1; Acvr1
10		EKS-MUM-00315	ENSMUSG00000032440	Tgfbr2
11		EKS-MUM-00316	ENSMUSG00000067336	Bmpr2
12		EKS-MUM-00317	ENSMUSG00000023047	Amhr2