※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (11) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MYL-00285	ENSMLUG00000006484	ACVR2A
2		EKS-MYL-00280	ENSMLUG00000010119	ACVR1
3		EKS-MYL-00281	ENSMLUG00000002433	ACVR1C
4		EKS-MYL-00287	ENSMLUG00000014783	BMPR2
5		EKS-MYL-00284	ENSMLUG00000001422	ACVRL1
6		EKS-MYL-00278	ENSMLUG00000015003	TGFBR1
7		EKS-MYL-00283	ENSMLUG00000009947	BMPR1A
8		EKS-MYL-00282	ENSMLUG00000009090	BMPR1B
9		EKS-MYL-00279	ENSMLUG00000004487	ACVR1B
10		EKS-MYL-00286	ENSMLUG00000017507	TGFBR2
11		EKS-MYL-00288	ENSMLUG00000017305	AMHR2