※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SUS-00246	ENSSSCG00000010360	BMPR1A
2		EKS-SUS-00248	ENSSSCG00000015669	ACVR2A
3		EKS-SUS-00251	ENSSSCG00000000271	AMHR2
4		EKS-SUS-00247	ENSSSCG00000000232	ACVRL1
5		EKS-SUS-00243	ENSSSCG00000000233	ACVR1B
6		EKS-SUS-00242	ENSSSCG00000005382	TGFBR1
7		EKS-SUS-00241	ENSSSCG00000023995	TGFBR1
8		EKS-SUS-00250	ENSSSCG00000016113	BMPR2
9		EKS-SUS-00249	ENSSSCG00000011257	ACVR2B
10		EKS-SUS-00252	ENSSSCG00000011226	TGFBR2; LOC100038019
11		EKS-SUS-00244	ENSSSCG00000015874	ACVR1
12		EKS-SUS-00245	ENSSSCG00000015873	ACVR1C