※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM), includes protein phosphatases which dependent on manganese/magnesium ions (Mn2+/Mg2+). PPM family contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determine the substrate recognition and function diversity. Like PPP family, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is the largest protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor proteins (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (16) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-MOD-00031	ENSMODG00000014795	PP2D1
2		EPS-MOD-00023	ENSMODG00000019241	PPM1K
3		EPS-MOD-00024	ENSMODG00000016297	PPM1L
4		EPS-MOD-00033	ENSMODG00000014325	PPM1H
5		EPS-MOD-00029	ENSMODG00000017715	PPM1F
6		EPS-MOD-00026	ENSMODG00000014637	PPM1E
7		EPS-MOD-00019	ENSMODG00000000678	PPM1B
8		EPS-MOD-00028	ENSMODG00000015646	PPM1G
9		EPS-MOD-00021	ENSMODG00000014156	PPM1D
10		EPS-MOD-00001	ENSMODG00000011559	PPTC7
11		EPS-MOD-00022	ENSMODG00000015921	ILKAP
12		EPS-MOD-00032	ENSMODG00000009407	TAB1
13		EPS-MOD-00027	ENSMODG00000002299	PHLPP2
14		EPS-MOD-00030	ENSMODG00000011632	PPM1M
15		EPS-MOD-00020	ENSMODG00000008615	PPM1A
16		EPS-MOD-00025	ENSMODG00000005218	PHLPP1