※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAG-00381	ENSTGUG00000016322
2		EKS-TAG-00361	ENSTGUG00000016226
3		EKS-TAG-00353	ENSTGUG00000016297
4		EKS-TAG-00352	ENSTGUG00000016405
5		EKS-TAG-00364	ENSTGUG00000016398
6		EKS-TAG-00393	ENSTGUG00000016493	PAK4
7		EKS-TAG-00386	ENSTGUG00000016636
8		EKS-TAG-00323	ENSTGUG00000010875	TNIK
9		EKS-TAG-00326	ENSTGUG00000004384	PAK3
10		EKS-TAG-00412	ENSTGUG00000000075
11		EKS-TAG-00397	ENSTGUG00000000005
12		EKS-TAG-00390	ENSTGUG00000016082
13		EKS-TAG-00405	ENSTGUG00000016026
14		EKS-TAG-00335	ENSTGUG00000000289	STK10
15		EKS-TAG-00406	ENSTGUG00000016145
16		EKS-TAG-00400	ENSTGUG00000016774
17		EKS-TAG-00365	ENSTGUG00000016741
18		EKS-TAG-00351	ENSTGUG00000016760
19		EKS-TAG-00399	ENSTGUG00000016738
20		EKS-TAG-00356	ENSTGUG00000010255	STRADB
21		EKS-TAG-00342	ENSTGUG00000008038	MYO3B
22		EKS-TAG-00333	ENSTGUG00000010378	SLK
23		EKS-TAG-00359	ENSTGUG00000016946
24		EKS-TAG-00403	ENSTGUG00000015233
25		EKS-TAG-00373	ENSTGUG00000015265
26		EKS-TAG-00339	ENSTGUG00000007255	PAK6
27		EKS-TAG-00396	ENSTGUG00000015000
28		EKS-TAG-00358	ENSTGUG00000015007
29		EKS-TAG-00324	ENSTGUG00000003240	NRK
30		EKS-TAG-00357	ENSTGUG00000003047
31		EKS-TAG-00331	ENSTGUG00000003029
32		EKS-TAG-00336	ENSTGUG00000007554	STK39
33		EKS-TAG-00377	ENSTGUG00000003740
34		EKS-TAG-00354	ENSTGUG00000011049	STK24
35		EKS-TAG-00383	ENSTGUG00000003518
36		EKS-TAG-00398	ENSTGUG00000015843
37		EKS-TAG-00360	ENSTGUG00000015817
38		EKS-TAG-00404	ENSTGUG00000015957
39		EKS-TAG-00413	ENSTGUG00000015383
40		EKS-TAG-00363	ENSTGUG00000015498
41		EKS-TAG-00375	ENSTGUG00000015568
42		EKS-TAG-00395	ENSTGUG00000015592
43		EKS-TAG-00411	ENSTGUG00000015515
44		EKS-TAG-00380	ENSTGUG00000012023	STK3
45		EKS-TAG-00402	ENSTGUG00000014907
46		EKS-TAG-00372	ENSTGUG00000006415
47		EKS-TAG-00407	ENSTGUG00000014365
48		EKS-TAG-00355	ENSTGUG00000014357
49		EKS-TAG-00389	ENSTGUG00000014354
50		EKS-TAG-00329	ENSTGUG00000002002	MAP4K3
51		EKS-TAG-00392	ENSTGUG00000014596
52		EKS-TAG-00379	ENSTGUG00000014586
53		EKS-TAG-00366	ENSTGUG00000014645
54		EKS-TAG-00369	ENSTGUG00000014676
55		EKS-TAG-00387	ENSTGUG00000014689
56		EKS-TAG-00391	ENSTGUG00000014739
57		EKS-TAG-00362	ENSTGUG00000014731
58		EKS-TAG-00388	ENSTGUG00000014716
59		EKS-TAG-00382	ENSTGUG00000014769
60		EKS-TAG-00368	ENSTGUG00000013724
61		EKS-TAG-00367	ENSTGUG00000013704
62		EKS-TAG-00376	ENSTGUG00000013675
63		EKS-TAG-00410	ENSTGUG00000013686
64		EKS-TAG-00374	ENSTGUG00000013955
65		EKS-TAG-00408	ENSTGUG00000013856
66		EKS-TAG-00409	ENSTGUG00000013861
67		EKS-TAG-00346	ENSTGUG00000013873
68		EKS-TAG-00334	ENSTGUG00000006182	PAK7
69		EKS-TAG-00327	ENSTGUG00000006107	STK25
70		EKS-TAG-00341	ENSTGUG00000006253
71		EKS-TAG-00337	ENSTGUG00000006304	TAOK1
72		EKS-TAG-00343	ENSTGUG00000001939	STRADA
73		EKS-TAG-00328	ENSTGUG00000005832	PAK2
74		EKS-TAG-00371	ENSTGUG00000001397
75		EKS-TAG-00345	ENSTGUG00000001058
76		EKS-TAG-00338	ENSTGUG00000001156	MYO3A
77		EKS-TAG-00340	ENSTGUG00000009900	MAP4K4
78		EKS-TAG-00325	ENSTGUG00000013034	PAK1
79		EKS-TAG-00350	ENSTGUG00000017522
80		EKS-TAG-00348	ENSTGUG00000017512
81		EKS-TAG-00347	ENSTGUG00000017514
82		EKS-TAG-00401	ENSTGUG00000017521
83		EKS-TAG-00378	ENSTGUG00000009171	TAOK3
84		EKS-TAG-00332	ENSTGUG00000013168	MAP4K5
85		EKS-TAG-00370	ENSTGUG00000017214
86		EKS-TAG-00394	ENSTGUG00000017535
87		EKS-TAG-00344	ENSTGUG00000017537
88		EKS-TAG-00384	ENSTGUG00000017061
89		EKS-TAG-00330	ENSTGUG00000005057	STK4
90		EKS-TAG-00385	ENSTGUG00000000423	OXSR1
91		EKS-TAG-00349	ENSTGUG00000000383