Canis familiaris      TK      Src

※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusEKPD IDGene IDGene Name
1
EKS-CAF-00366
ENSCAFG00000003995
FYN
2
EKS-CAF-00372
ENSCAFG00000007963
BLK
3
EKS-CAF-00375
ENSCAFG00000012942
SRMS
4
EKS-CAF-00373
ENSCAFG00000012070
FGR
5
EKS-CAF-00374
ENSCAFG00000004055
FRK
6
EKS-CAF-00367
ENSCAFG00000008755
SRC
7
EKS-CAF-00368
ENSCAFG00000018362
CFA.42409; YES1
8
EKS-CAF-00371
ENSCAFG00000010625
LCK
9
EKS-CAF-00369
ENSCAFG00000007034
LYN
10
EKS-CAF-00370
ENSCAFG00000007122
HCK