※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-EQC-00276	ENSECAG00000015269	TGFBR2
2		EKS-EQC-00275	ENSECAG00000019616	ACVR2B
3		EKS-EQC-00270	ENSECAG00000019682	ACVR1C
4		EKS-EQC-00268	ENSECAG00000011686	ACVR1B
5		EKS-EQC-00274	ENSECAG00000000138	ACVR2A
6		EKS-EQC-00271	ENSECAG00000012140	BMPR1B
7		EKS-EQC-00267	ENSECAG00000004757	TGFBR1
8		EKS-EQC-00273	ENSECAG00000009133	ACVRL1
9		EKS-EQC-00269	ENSECAG00000018902	ACVR1
10		EKS-EQC-00272	ENSECAG00000020461	BMPR1A
11		EKS-EQC-00278	ENSECAG00000020247	AMHR2
12		EKS-EQC-00277	ENSECAG00000025141	BMPR2