※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (10) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MOD-00272	ENSMODG00000012679	TGFBR1
2		EKS-MOD-00281	ENSMODG00000027777	AMHR2
3		EKS-MOD-00274	ENSMODG00000019262	BMPR1B
4		EKS-MOD-00276	ENSMODG00000011158	BMPR1A
5		EKS-MOD-00279	ENSMODG00000015155	TGFBR2
6		EKS-MOD-00277	ENSMODG00000003295	ACVR2A
7		EKS-MOD-00278	ENSMODG00000008889	ACVR2B
8		EKS-MOD-00280	ENSMODG00000016287	BMPR2
9		EKS-MOD-00275	ENSMODG00000004431	ACVR1
10		EKS-MOD-00273	ENSMODG00000004411	ACVR1C