※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (21) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAR-00358	ENSTRUG00000007134	ACVR1C
2		EKS-TAR-00359	ENSTRUG00000007007	ACVR1
3		EKS-TAR-00368	ENSTRUG00000013188	TGFBR2 (2 of 2); TGFBR2 (1 of 2)
4		EKS-TAR-00363	ENSTRUG00000011026	BMPR1A
5		EKS-TAR-00361	ENSTRUG00000013761	BMPR1B (2 of 3)
6		EKS-TAR-00370	ENSTRUG00000007583	TGFBR2 (2 of 2); TGFBR2 (1 of 2)
7		EKS-TAR-00367	ENSTRUG00000002691	BMPR1B (1 of 3)
8		EKS-TAR-00373	ENSTRUG00000014259	AMHR2
9		EKS-TAR-00369	ENSTRUG00000006256	BMPR2
10		EKS-TAR-00356	ENSTRUG00000012489	O73801_TAKRU
11		EKS-TAR-00357	ENSTRUG00000012480	ACVR1B (1 of 2); ACVR1B (2 of 2)
12		EKS-TAR-00364	ENSTRUG00000012725	ACVRL1
13		EKS-TAR-00371	ENSTRUG00000001801	ACVR2A (2 of 3)
14		EKS-TAR-00362	ENSTRUG00000015474
15		EKS-TAR-00374	ENSTRUG00000000927	ACVR2A (3 of 3)
16		EKS-TAR-00360	ENSTRUG00000005555	BMPR1B (3 of 3)
17		EKS-TAR-00355	ENSTRUG00000004751	TGFBR1 (1 of 2)
18		EKS-TAR-00372	ENSTRUG00000000430
19		EKS-TAR-00365	ENSTRUG00000004589	ACVR2A (1 of 3)
20		EKS-TAR-00366	ENSTRUG00000004161	ACVR2B
21		EKS-TAR-00375	ENSTRUG00000004386	TGFBR1 (2 of 2)