Rattus norvegicus      TK      Src

※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.


There are 11 genes.  Reviewed (6 or Unreviewed (5

No.StatusEKPD IDGene IDGene Name
1
EKS-RAN-00389
ENSRNOG00000012987
rCG_38544; Ptk6; Ptk6_predicted
2
EKS-RAN-00388
ENSRNOG00000013003
rCG_38599; Srms
3
EKS-RAN-00385
ENSRNOG00000009912
Fgr
4
EKS-RAN-00381
ENSRNOG00000037227
Yes1
5
EKS-RAN-00384
ENSRNOG00000009705
Lck
6
EKS-RAN-00380
ENSRNOG00000009495
Src; rCG_32093
7
EKS-RAN-00383
ENSRNOG00000009331
Hck
8
EKS-RAN-00387
ENSRNOG00000000543
Gask; Frk
9
EKS-RAN-00379
ENSRNOG00000000596
Fyn
10
EKS-RAN-00386
ENSRNOG00000010798
rCG_52180; Blk
11
EKS-RAN-00382
ENSRNOG00000008180
Lyn