※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (19) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAA-00343	ENSGACG00000010017
2		EKS-GAA-00353	ENSGACG00000018107	ACVR2B (2 of 2)
3		EKS-GAA-00354	ENSGACG00000006672	AMHR2
4		EKS-GAA-00350	ENSGACG00000003140	TGFBR2 (1 of 2)
5		EKS-GAA-00345	ENSGACG00000015083	ACVR2A
6		EKS-GAA-00348	ENSGACG00000003781	TGFBR2 (2 of 2)
7		EKS-GAA-00342	ENSGACG00000007776	BMPR1B (1 of 2); BMPR1B (2 of 2)
8		EKS-GAA-00337	ENSGACG00000009013	ACVR1B (1 of 2)
9		EKS-GAA-00344	ENSGACG00000009008	ACVRL1
10		EKS-GAA-00346	ENSGACG00000016690	ACVR2B (1 of 2)
11		EKS-GAA-00340	ENSGACG00000016869	BMPR1B (1 of 2); BMPR1B (2 of 2)
12		EKS-GAA-00338	ENSGACG00000000719	ACVR1B (2 of 2)
13		EKS-GAA-00341	ENSGACG00000011543	BMPR1A
14		EKS-GAA-00352	ENSGACG00000000299	BMPR2 (2 of 2)
15		EKS-GAA-00351	ENSGACG00000000264
16		EKS-GAA-00336	ENSGACG00000000970	TGFBR1
17		EKS-GAA-00349	ENSGACG00000013817	BMPR2 (1 of 2)
18		EKS-GAA-00339	ENSGACG00000005810	ACVR1
19		EKS-GAA-00347	ENSGACG00000005819	ACVR1C