※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAG-00297	ENSTGUG00000010107	BMPR2
2		EKS-TAG-00293	ENSTGUG00000016862	ACVR1C
3		EKS-TAG-00295	ENSTGUG00000011916	ACVR2A
4		EKS-TAG-00299	ENSTGUG00000003267	ACVRL1
5		EKS-TAG-00291	ENSTGUG00000003164	BMPR1B
6		EKS-TAG-00289	ENSTGUG00000003248	ACVR1B
7		EKS-TAG-00296	ENSTGUG00000003590	TGFBR2
8		EKS-TAG-00298	ENSTGUG00000003987
9		EKS-TAG-00290	ENSTGUG00000012182	ACVR1
10		EKS-TAG-00300	ENSTGUG00000014944
11		EKS-TAG-00288	ENSTGUG00000006726	TGFBR1
12		EKS-TAG-00292	ENSTGUG00000005714	BMPR1A
13		EKS-TAG-00294	ENSTGUG00000000545	ACVR2B