※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (19) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-DAR-00615	ENSDARG00000052142	LOC559222; ACVR1B (1 of 2)
2		EKS-DAR-00620	ENSDARG00000019728	bmpr1a, zgc:136731; bmpr1aa; CH211-134M17.5-001
3		EKS-DAR-00619	ENSDARG00000045097	bmpr1ab
4		EKS-DAR-00627	ENSDARG00000059363	LOC100334928; TGFBR2 (2 of 2)
5		EKS-DAR-00618	ENSDARG00000014986	acvr1l; acvr1, alk8
6		EKS-DAR-00616	ENSDARG00000018968	acvr1b
7		EKS-DAR-00629	ENSDARG00000055136	si:dkey-101k6.5
8		EKS-DAR-00621	ENSDARG00000018179	acvrl1
9		EKS-DAR-00626	ENSDARG00000034541	tgfbr2
10		EKS-DAR-00624	ENSDARG00000079944	ACVR2A (2 of 2)
11		EKS-DAR-00617	ENSDARG00000031219	bmpr1bb
12		EKS-DAR-00631	ENSDARG00000086172	LOC100331105; CABZ01079442.1; ACVR1C
13		EKS-DAR-00630	ENSDARG00000011941	bmpr2a
14		EKS-DAR-00613	ENSDARG00000042259	tgfbr1b
15		EKS-DAR-00622	ENSDARG00000011188	acvr2a
16		EKS-DAR-00614	ENSDARG00000017494	DKEY-24C2.2; tgfbr1a; DKEY-24C2.2-001
17		EKS-DAR-00628	ENSDARG00000044422	acvr2b
18		EKS-DAR-00625	ENSDARG00000020057	DKEY-56K23.1-001; bmpr2b
19		EKS-DAR-00623	ENSDARG00000041516	ACVR2B (2 of 2); LOC100331938