※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SAH-00264	ENSSHAG00000010152	ACVR2A
2		EKS-SAH-00268	ENSSHAG00000001044	AMHR2
3		EKS-SAH-00261	ENSSHAG00000017429	ACVR1
4		EKS-SAH-00260	ENSSHAG00000017075	ACVR1C
5		EKS-SAH-00257	ENSSHAG00000012059	ACVR1B
6		EKS-SAH-00262	ENSSHAG00000005672	BMPR1A
7		EKS-SAH-00265	ENSSHAG00000012498	ACVR2B
8		EKS-SAH-00266	ENSSHAG00000012515	TGFBR2
9		EKS-SAH-00267	ENSSHAG00000009795	BMPR2
10		EKS-SAH-00258	ENSSHAG00000016699	TGFBR1
11		EKS-SAH-00263	ENSSHAG00000011355	ACVRL1
12		EKS-SAH-00259	ENSSHAG00000010891	BMPR1B