※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (17) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TEN-00356	ENSTNIG00000016489	ACVR1
2		EKS-TEN-00359	ENSTNIG00000016488	ACVR1C
3		EKS-TEN-00364	ENSTNIG00000017166	ACVR2A
4		EKS-TEN-00366	ENSTNIG00000013283	BMPR2
5		EKS-TEN-00368	ENSTNIG00000006473	TGFBR2 (1 of 2)
6		EKS-TEN-00365	ENSTNIG00000013820	TGFBR2 (2 of 2)
7		EKS-TEN-00360	ENSTNIG00000009054	BMPR1B (1 of 2)
8		EKS-TEN-00370	ENSTNIG00000001859	TGFBR1 (1 of 2)
9		EKS-TEN-00362	ENSTNIG00000018688	BMPR1A (1 of 2)
10		EKS-TEN-00367	ENSTNIG00000014872	ACVR2B
11		EKS-TEN-00354	ENSTNIG00000018951	TGFBR1 (2 of 2)
12		EKS-TEN-00357	ENSTNIG00000014589	ACVR1B (2 of 3)
13		EKS-TEN-00369	ENSTNIG00000019387
14		EKS-TEN-00361	ENSTNIG00000002260
15		EKS-TEN-00358	ENSTNIG00000015803	BMPR1B (2 of 2)
16		EKS-TEN-00355	ENSTNIG00000015070	ACVR1B (3 of 3)
17		EKS-TEN-00363	ENSTNIG00000015071	ACVRL1