※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-OTG-00289	ENSOGAG00000000125	TGFBR2
2		EKS-OTG-00282	ENSOGAG00000029484	ACVR1B
3		EKS-OTG-00286	ENSOGAG00000004094	ACVRL1
4		EKS-OTG-00287	ENSOGAG00000004021	ACVR2A
5		EKS-OTG-00281	ENSOGAG00000004163	TGFBR1
6		EKS-OTG-00284	ENSOGAG00000011965	ACVR1C
7		EKS-OTG-00283	ENSOGAG00000011662	ACVR1
8		EKS-OTG-00292	ENSOGAG00000028440	AMHR2
9		EKS-OTG-00290	ENSOGAG00000007765	BMPR2
10		EKS-OTG-00285	ENSOGAG00000003063	BMPR1B
11		EKS-OTG-00288	ENSOGAG00000032563	ACVR2B
12		EKS-OTG-00291	ENSOGAG00000010762	BMPR1A